Resumen Introducción: este estudio pretende describir el perfil de las interconsultas enviadas al equipo de odontología hospitalaria provenientes de pacientes internados en el Hospital Criança Conceição de Porto Alegre, Rio Grande do Sul, Brasil, en el período de enero de 2012 a julio de 2018. Métodos: estudio descriptive retrospectivo en el que se evaluaron 193 historias clínicas odontológicas electrónicas para extraer los siguientes datos: sexo y edad del paciente, descripción de la interconsulta realizada por otros profesionales de salud y conducta del cirujano dentista frente al problema presentado. Resultados: el 61,6% de los pacientes fue de sexo masculino y la edad promedio general fue 10,5 años. Las interconsultas más solicitadas para los cirujanos dentistas fueron provenientes del área de oncohematología (75,12%) y el motivo predominante fue sobre el cuidado bucal a pacientes pre y posquimioterapia (40,4%). El diagnóstico que más encontraron los dentistas fue mucositis (17,6%) y lesiones de caries (16%). Hubo ausencia de enfermedades bucales en 23,8% de los casos. Las intervenciones más realizadas por el equipo de odontología fueron aplicaciones de laserterapia (57,5%) y orientaciones de higiene bucal (49,1%) en ámbito hospitalario; en sillón dental y sala quirúrgica, fueron exodoncias (27,7%) y restauraciones (11,7%). Conclusiones: el perfil de las interconsultas enviadas al equipo de odontología hospitalaria provenientes de pacientes internados en el Hospital Criança Conceição de Porto Alegre, Rio Grande do Sul, Brasil, es inadecuado, pues se demostró falta de manejo transdisciplinar que incluya odontología, además de la necesidad de un mejor aprovechamiento de los recursos de tecnología de información e historias clínicas más objetivas y que permitan obtener más fácilmente la información de salud de los pacientes.

Abstract Introduction: this study aimed to describe the profile of the referrals sent to the hospital dentistry team from patients in Hospital Criança Conceição in Porto Alegre, Rio Grande do Sul, Brazil, from January 2012 to July 2018. Methods: a descriptive, retrospective study was conducted, evaluating 193 electronic dental records to extract the following data: patient’s sex and age, description of the referral made by other health professionals and the dentist’s behavior in solving the presented problem. Results: 61.6% of patients were male and the mean age of all patients was 10.5 years. Most dental referrals came from the oncohematology area (75.12%) and the predominant reason was pre- and post-chemotherapy patients’ dental care (40.4%). The diagnosis most commonly found by dentists was mucositis (17.6%) and caries (16%). There was absence of oral diseases in 23.8% of cases. The interventions most commonly performed by the hospital dentistry team were laser therapy (57.5%) and oral hygiene instructions (49.1%) in the hospital setting, while procedures in dental offices and surgical rooms included exodontias (27.7%) and restorations (11.7%). Conclusions: the profile of referrals sent to the hospital dentistry team from patients hospitalized in the Hospital Criança Conceição in Porto Alegre, Rio Grande do Sul, Brazil, is inadequate, since there was a lack of transdisciplinary management including dental care, in addition to poor use of information technology resources and lack of more objective medical records for easy retrieval of patient health information.

Daniel Krige's influence on soil science, and on soil survey in particular, has been profound. From the 1920s onwards soil surveyors made their maps by classifying the soils and drawing boundaries between the classes they recognized. By the 1960s many influential pedologists were convinced that if one knew to which class of soil a site belonged then one would be able to predict the soil's properties there. At the same time, engineers began to realize that prediction from such maps was essentially a statistical matter and to apply classical sampling theory. Such methods, though sound, proved inefficient because they failed to take account of the spatial dependence within the classes. Matters changed dramatically in the 1970s when soil scientists learned of the work of Daniel Krige and Georges Matheron's theory of regionalized variables. Statistical pedologists (pedometricians) first linked R.A. Fisher's analysis of variance to regionalized variables via spatial hierarchical designs to estimate spatial components of variance. They then applied the mainstream geostatistical methods of spatial analysis and kriging to map plant nutrients, trace elements, pollutants, salt, and agricultural pests in soil, which has led to advances in modern precision agriculture. They were among the first Earth scientists to use nonlinear statistical estimation for modelling variograms and to make the programmed algorithms publicly available. More recently, pedometricians have turned to likelihood methods, specifically residual maximum likelihood (REML), to combine fixed effects, such as trend and external variables, with spatially correlated variables in linear mixed models for spatial prediction. They have also explored nonstationary variances with wavelets and by spectral tempering, although it is not clear how the results should be used for prediction. This paper illustrates the most significant advances, with results from research projects.

INTRODUÇÃO: A determinação precisa do volume mamário pode melhorar o resultado dos procedimentos de reconstrução. O objetivo deste estudo é correlacionar a mensuração pré-operatória do volume mamário utilizando o método de conchas plásticas e a aplicação intraoperatória do princípio de Arquimedes para a avaliação volumétrica das mamas, em pacientes submetidas a reconstrução mamária imediata utilizando expansores permanentes, portadoras de mamas de pequeno volume e grau ptótico leve. MÉTODO: Dez pacientes foram incluídas em um estudo retrospectivo não-randomizado. O volume da mama foi mensurado, no pré-operatório, com conchas plásticas com volumes predeterminados e, no período intraoperatório, com o método de Arquimedes. Expansor apropriado permanente foi selecionado e inserido de maneira retromuscular. A equipe classificou a simetria da mama como pobre, boa ou muito boa. RESULTADOS: As diferenças entre as medidas pré e intraoperatórias foram estatisticamente significantes (P < 0,01, teste t de Student). Os valores pré-operatórios foram subestimados em 70% dos casos e foram 15% menores que os valores intraoperatórios. CONCLUSÕES: A avaliação do volume da mama em procedimentos de reconstrução imediata utilizando expansores permanentes pode ser aperfeiçoada pela combinação de diferentes técnicas de mensuração pré e intraoperatórias, levando a resultados mais previsíveis. O método de conchas plásticas de volume preestabelecido tende a subestimar o volume ressecado da mama quando comparado aos valores obtidos com método de mensuração intraoperatória utilizando o princípio de Arquimedes.

BACKGROUND: The accurate determination of breast volume improves the outcome of reconstructive procedures. The aim of the present study is to correlate the preoperative measurement of breast volume using the plastic shells method with the intraoperative application of the Archimedes principle to assess breast volume in immediate breast reconstruction using permanent expanders in patients having breasts with a small volume and mild ptosis grade. METHODS: Ten patients were enrolled in this retrospective nonrandomized study. Breast volume was measured preoperatively using fixed-volume plastic shells and intraoperatively using the Archimedes method. An appropriate permanent expander was selected and inserted in a retromuscular position. The team classified breast symmetry as poor, good, or very good. RESULTS: Differences between pre- and intraoperative measurements were statistically significant (P < 0.01, Student's t-test). Preoperative values were lower than intraoperative values by 15% in 70% of the cases. CONCLUSIONS: Breast volume assessment in immediate reconstruction procedures with permanent expanders can be improved and yield more predictable results by the combined use of different pre- and intraoperative measuring techniques. The method that uses fixed-volume plastic shells tends to underestimate the resected breast volume compared to the intraoperative method that uses the Archimedes principle.

Malaria is a parasitic disease of major global health significance that causes an estimated 2.7 million deaths each year. In this review we describe the burden of malaria and discuss the complicated life cycle of Plasmodium falciparum, the parasite responsible for most of the deaths from the disease, before reviewing the evidence that suggests that a malaria vaccine is an attainable goal. Significant advances have recently been made in vaccine science, and we review new vaccine technologies and the evaluation of candidate malaria vaccines in human and animal studies worldwide. Finally, we discuss the prospects for a malaria vaccine and the need for iterative vaccine development as well as potential hurdles to be overcome.

La malaria es una enfermedad parasitaria de enorme trascendencia para la salud mundial, que según se estima causa unos 2,7 millones de defunciones cada año. En esta revisión describimos la carga de malaria y analizamos el complejo ciclo de vida de Plasmodium falciparum, el parásito responsable de la mayoría de las defunciones debidas a esa enfermedad, para pasar a continuación a examinar la evidencia indicativa de que la obtención de una vacuna antimalárica es una meta alcanzable. A la vista de los importantes progresos realizados últimamente en el campo de la vacunología, examinamos las nuevas tecnologías surgidas en ese terreno y hacemos una evaluación de las protovacunas antimaláricas empleadas en estudios realizados en el hombre y en animales en todo el mundo. Por último, nos referimos a las perspectivas de obtener una vacuna contra la malaria y a la necesidad de desarrollarla de forma iterativa, así como a las dificultades que podrían aparecer.

Le paludisme est une maladie parasitaire d'importance majeure dans le monde entier, qui provoquerait, selon les estimations, 2,7 millions de décès chaque année. Dans le présent article, les auteurs décrivent la charge du paludisme et expliquent le cycle de vie complexe de Plasmodium falciparum, le parasite responsable de la plupart des décès dus à cette maladie. Ils passent ensuite en revue les données permettant de penser que le vaccin antipaludique est un objectif réalisable. La vaccinologie a fait récemment de grands progrès et les auteurs font le point, à partir d'études publiées dans le monde entier, des nouvelles technologies et évaluent les vaccins candidats chez l'homme et l'animal. Ils concluent en examinant les perspectives dans ce domaine, la nécessité d'un développement itératif pour ce type de vaccins ainsi que les obstacles potentiels à surmonter.